HCID 66783135, compound → HCID 59159267, compound

Participants

Reaction Steps

The title compound was produced in analogy with example 94, steps E and F. Thus, (S)-2-(3-trifluoromethoxy-phenylamino)-propionic acid (intermediate 25) was coupled in step E with (2,2-dimethoxy-ethyl)-[4-((S)-4-triethylsilanyloxy-6-aza-spiro[2.5]oct-6-yl)-butyl]-amine (example 94D), leading to (S)-2-(3-trifluoromethoxy-phenylamino)-N-(2,2-dimethoxy-ethyl)-N-[4-((S)-4-hydroxy-6-aza-spiro[2.5]oct-6-yl)-butyl]-propionamide, which was converted to the title compound in step F. Light yellow gum, MS: 456.4 (M+H)+.

Provenance & Evidence