HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 4-Iodo-1-methylpyridin-2(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-Iodo-1,2-dihydropyridin-2-one | HCID 20582535 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 4-Iodo-1-methylpyridin-2(1H)-one | HCID 53408009 | 53% |
Reaction Steps
To a solution of 4-iodopyridin-2(1H)-one (3 g, 0.013 mol) and K2CO3 (3.55 g, 0.026 mol) in DMF (30 mL) was added iodomethane (4.7 g, 0.033 mmol). The mixture was stirred at room temperature overnight. Water and EtOAc were added. The organic phase was dried over Na2SO4 and concentrated to give 4-iodo-1-methylpyridin-2(1H)-one (1.6 g, 53%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08138178B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-d1e20160aaba479d85d2fa884048b296 |
| Source note | uspto-grants-2012_03 |