2,2,2-Trifluoroethyl trifluoromethanesulfonate → 5-Bromo-1-(2,2,2-trifluoroethyl)pyridin-2(1H)-one

HRID 1096417Notes

Reaction equation

HRID 1096417 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5](=[O:8])[NH:6][CH:7]=1.FC(F)(F)S(O[CH2:15][C:16]([F:19])([F:18])[F:17])(=O)=O>>[Br:1][C:2]1[CH:3]=[CH:4][C:5](=[O:8])[N:6]([CH2:15][C:16]([F:19])([F:18])[F:17])[CH:7]=1

Participants

3

Reactant 2

HCID 803662,2,2-Trifluoroethyl trifluoromethanesulfonateHCID 5995285-Bromo-2-hydroxypyridine

Product 1

HCID 534080995-Bromo-1-(2,2,2-trifluoroethyl)pyridin-2(1H)-one

Procedure

5-bromo-1-(2,2,2-trifluoroethyl)pyridin-2(1H)-one was prepared from 5-bromopyridin-2(1H)-one and 2,2,2-trifluoroethyl trifluoromethanesulfonate following a procedure analogous to that described in Example 59 Step 1.

Sources & evidence

ORD record
ord-ff8a7702041a4223ae8ed345256cf5b6
Source dataset
uspto-grants-2012_03
Patent number
US08138178B2

Reaction notes

Loading…