Acetic Anhydride → Ethyl (acetyloxy)(4-chloro-3-nitrophenyl)acetate

HRID 1096473Notes

Reaction equation

HRID 1096473 reaction equation
[CH2:1]([O:3][C:4](=[O:17])[CH:5]([C:7]1[CH:12]=[CH:11][C:10]([Cl:13])=[C:9]([N+:14]([O-:16])=[O:15])[CH:8]=1)[OH:6])[CH3:2].[C:18](OC(=O)C)(=[O:20])[CH3:19]>N1C=CC=CC=1>[CH2:1]([O:3][C:4](=[O:17])[CH:5]([O:6][C:18](=[O:20])[CH3:19])[C:7]1[CH:12]=[CH:11][C:10]([Cl:13])=[C:9]([N+:14]([O-:16])=[O:15])[CH:8]=1)[CH3:2]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 86609828Ethyl (4-chloro-3-nitrophenyl)(hydroxy)acetate

Product 1

HCID 86609827Ethyl (acetyloxy)(4-chloro-3-nitrophenyl)acetate

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

To a solution (6 mL) of the compound (1.46 g) prepared in Example 22 in pyridine, acetic anhydride (2 mL) was added, and the mixture was stirred for 1 hour at room temperature. The title compound (135 mg) having the following physical data was obtained by concentrating the reaction mixture and azeotroping in toluene.

Sources & evidence

ORD record
ord-555d4c3cd5e8463eb2a81316404c49a5
Source dataset
uspto-grants-2012_03
Patent number
US08138335B2

Reaction notes

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