Dimethyl Sulfoxide → HCID 66781796, compound

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Reaction Steps

Under argon atmosphere, to a mixture of the compound (159 mg) prepared in Example 31, diisopropylethylamine (0.30 mL), dimethylsulfoxide (2 mL), and ethyl acetate (4 mL), sulfur trioxide pyridine complex (139 mg) were added at ice-cold temperature, and the mixture was stirred for 1 hour at the same temperature. Water was added to the reaction mixture, which was extracted with ethyl acetate. The organic layer was washed with water and saturated brine solution and was dried by anhydrous magnesium sulphate. The title compound (104 mg) having the following physical data was obtained by purifying the residue obtained by removing the solvent by silica gel column chromatography (n-hexane:ethyl acetate=3:1→2:1).

Provenance & Evidence