反应详情

Benzenesulfonyl chloride (140 mg, 0.79 mmol), NBu4HSO4 (24 mg, 0.07 mmol) and 4M aq. NaOH (2 mL) were, in that order, added to 3,4-Dihydropyrrolo[4,3,2-de]isoquinolin-5(1H)-one, Intermediate 1 (124 mg, 0.72 mmol) in DCM (10 mL). The reaction was stirred at room temperature for 2 h and then extracted with water and DCM (×2). The product seems to be only partially soluble in DCM and some solid material in the water layer was filtered off and added to the DCM layer, which was concentrated and dried to give 227 mg of the title compound, as a light brown solid. MS m/z 313 [M+H]+.

1. extractionextracted with water and DCM (×2)
2. filtrationsome solid material in the water layer was filtered off
3. additionadded to the DCM layer, which
4. concentrationwas concentrated
5. customdried