Trifluoroacetic acid methylene chloride → HCID 86624983, compound

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Reaction Steps

tert-Butyl 6-methyl-1-(phenylsulfonyl)-7-{[(trifluoromethyl)sulfonyl]oxy}-1,3,4,6-tetrahydro-5H-azepino[5,4,3-cd]indole-5-carboxylate, Intermediate 16 (12.6 mg, 0.022 mmol) was dissolved in a 50/50 mixture of DCM/TFA (1 mL) and left at room temperature for one hour. The evaporated crude product was purified by preparative HPLC (ACE C8 5 mm, water containing 0.1% TFA —CH3CN) to give 7.2 mg of the title compound as a light brown oil. MS m/z 474 [M+H]+.

Provenance & Evidence