Benzenesulfonyl chloride → HCID 59848832, compound

Participants

Reaction Steps

Tert-Butyl 3-oxo-1,3,4,6-tetrahydro-5H-azepino[5,4,3-cd]indole-5-carboxylate, Intermediate 17 (50 mg, 0.17 mmol), tetrabutylammonium hydrogensulfate (8 mg, 0.01 mmol) and benzenesulfonyl chloride (25 μl, 0.19 mmol) were dissolved in DCM (2 ml). 2.5 M NaOH (77 μl) was added. The mixture was stirred for 1 h at room temperature. The DCM phase was collected and washed with NaHCO3(sat.) and water. Evaporation gave a residue that was purified on silica 8-66% EtOAc in petroleum ether 45-60°. Obtained 42.4 mg of the title compound as a clear glass. MS (ESI+) m/z 371 [M+H-isobutene]+.

Provenance & Evidence