Acetic Acid → HCID 66785162, compound

Participants

Reaction Steps

tert-Butyl 3-oxo-1-(phenylsulfonyl)-1,3,4,6-tetrahydro-5H-azepino[5,4,3-cd]indole-5-carboxylate Intermediate 18 (11 mg, 0.03 mmol) was dissolved in DCM (1 ml). TFA (0.5 ml) was added and the solution was heated to boiling, and then evaporated. The residue was dissolved in EtOH (3 ml). Sodium borohydride (7.5 mg, 0.2 mmol) was added. The reaction mixture was stirred at room temperature for 45 min. The solution was acidified with acetic acid, and evaporated. The evaporation procedure was repeated twice with the addition of methanol. The crude product was purified by preparative HPLC (ACE C8 5 mm, water containing 0.1% TFA-CH3CN) to give the title compound, 7 mg.

Provenance & Evidence