反应详情

To (−)-7-amino-5-benzyl-7-methyl-5-azaspiro[2.4]heptane D-mandelate (22.43 g, optical purity: 98% e.e.), 10% Aqueous sodium hydroxide and toluene were added, and the mixture was stirred at room temperature. Thereafter, the toluene layer was separated, washed with saturated brine, and dried with sodium sulfate. The desiccant was removed through filtration, and the filtrate was concentrated under reduced pressure, to thereby yield the title product as pale yellow oil (16.13 g, optical purity: 98% e.e.).

1. customThereafter, the toluene layer was separated
2. washwashed with saturated brine
3. dry with materialdried with sodium sulfate
4. customThe desiccant was removed through filtration
5. concentrationthe filtrate was concentrated under reduced pressure