HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate → HCID 123430768, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate | HCID 151348 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | (3S)-4-[[(1,1-Dimethylethoxy)carbonyl]amino]-3-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]butanoic acid | HCID 17040124 | — |
| Reactant | HCID 66786519 | HCID 66786519 | — |
| Solvent | 4-Methylmorpholine | HCID 7972 | — |
| Product | HCID 123430768 | HCID 123430768 | — |
Reaction Steps
Piperidine (R)-1-(3-methoxypropyl)-2-(piperidin-3-yl)-1H-benzo[d]imidazole (138C) (3.19 g, 11.3 mmol) was acylated with the protected butanoic acid 138B (5 g, 11.4 mmol) in N-methylmorpholine using the standard BOP coupling reaction similar to HATU procedure of Example 7, Step E yielding tert-butyl (S)-2-(9H-fluoren-9-ylamino)-4-((R)-3-(1-(3-methoxypropyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)-4-oxobutylcarbamate (1380) (7.9 g, 11.4 mmol). ESI-MS: m/z 696.6 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08138168B1 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-a2c4c4880f4f4dd8826062aa0599d843 |
| Source note | uspto-grants-2012_03 |