HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → HCID 66785967, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | (2-Aminopyrimidin-5-yl)boronic acid | HCID 17750211 | — |
| Reactant | HCID 56933214 | HCID 56933214 | — |
| Reactant | HCID 66791847 | HCID 66791847 | — |
| Product | HCID 66785967 | HCID 66785967 | 14.4% |
Reaction Steps
Suzuki coupling of 145A with 2-aminopyrimidin-5-ylboronic acid (145E) was carried out analogously to the synthesis of Compound 613 (Example 6, Step B). The crude Boc-protected intermediate was de-protected with TFA using procedure similar to that for the synthesis of Compound 72 from Compound 6B (Example 6, Step C). The crude product was purified by preparative HPLC using 15% CH3CN/water as mobile phase. Compound 509 was obtained in 14.4% yield over two steps (17.8 mg), MS: MH+=502.4.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08138168B1 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-b1ac20e3b9804136a61e4a957378c7f6 |
| Source note | uspto-grants-2012_03 |