Ethyl Acetate → 3-(1,3-Thiazol-4-yl)propanal

Participants

Reaction Steps

NaIO4 (2.40 g, 11.3 mmol) was added to a sol. of (rac.)-4-thiazol-4-ylbutane-1,2-diol (1.62 g, 9.37 mmol) in THF (20 mL) and water (10 mL). The mixture was stirred for 2 h, and EtOAc was added. The mixture was washed with brine, and with aq. sat. NaHCO3. The org. extracts were dried over MgSO4, filtered, and the solvents were removed under reduced pressure. Drying the residue under high vacuum yielded the crude title compound (1.04 g, 79%), which was used further without purification. LC-MS: tR=0.32, ES+: 142.11.

Provenance & Evidence