Diethyl Ether → HCID 66783955, compound

Participants

Reaction Steps

A sol. of (rac.)-2-(tert-butyldimethylsilanyloxy)-5-[1-(tert-butyldimethylsilanyloxy)ethyl]-1,3-dichlorobenzene (188 mg, 0.432 mmol) and CS2CO3 (76.2 mg, 0.126 mmol) in a mixture of DMF (0.50 mL) and water (50 μL) was stirred at rt overnight. Et2O (75 mL) was added. The sol. was washed with brine, dried over MgSO4, filtered, and the solvents were removed under reduced pressure. Purification by FC(CH2Cl2) yielded the title compound (122 mg, 88%). LC-MS: tR=1.15 min.

Provenance & Evidence