6-[Cyclopropyl-(3-methoxy-2-methylbenzyl)carbamoyl]-7-[2-(2-hydroxyethoxy)thiazol-5-yl]-3,9-diazabicyclo[3.3.1]non-6-ene-3,9-dicarboxylic acid di-tert-butyl ester → 7-{2-[2-(4-Chloro-1-methyl-5-trifluoromethyl-1H-pyrazol-3-yloxy)-ethoxy]thiazol-5-yl}-6-[cyclopropyl-(3-methoxy-2-methylbenzyl)carbamoyl]-3,9-diazabicyclo[3.3.1]non-6-ene-3,9-dicarboxylic acid di-tert-butyl ester

Participants

Role	Name	HCID	Charge
Reactant	6-[Cyclopropyl-(3-methoxy-2-methylbenzyl)carbamoyl]-7-[2-(2-hydroxyethoxy)thiazol-5-yl]-3,9-diazabicyclo[3.3.1]non-6-ene-3,9-dicarboxylic acid di-tert-butyl ester	HCID 68570797	—
Reactant	HCID 178481948	HCID 178481948	—
Product	7-{2-[2-(4-Chloro-1-methyl-5-trifluoromethyl-1H-pyrazol-3-yloxy)-ethoxy]thiazol-5-yl}-6-[cyclopropyl-(3-methoxy-2-methylbenzyl)carbamoyl]-3,9-diazabicyclo[3.3.1]non-6-ene-3,9-dicarboxylic acid di-tert-butyl ester	HCID 77516352	—

Reaction Steps

This compound is prepared from compound E9 and 4-chloro-1-methyl-5-trifluoromethyl-1H-pyrazol-3-ol (Eur. Pat. Appl., 1989, EP 304409), according to the above-described procedure A. LC-MS: tR=1.23 min, ES+: 867.40.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08138340B2
Source dataset	uspto-grants-2012_03
ORD ID	ord-e44df897dec84e7ab2176f9ae30d56e8
Source note	uspto-grants-2012_03