Hydrochloric Acid → HCID 11636062, compound

Participants

Reaction Steps

A sol. of compound F6 (3.29 mmol; 2.86 g) in CH2Cl2 (16.5 mL) at 0° C. was treated with HCl (4.0 M in dioxane; 16.5 mL, 66 mmol) and stirred for 1 h at rt. Sat. aq. Na2CO3 (100 mL) was added and the aq. layer was extracted with EtOAc (3×100 mL), dried over MgSO4, filtered and the solvents were removed under reduced pressure. Purification of the residue by FC(CH2Cl2/MeOH 75:25) yielded the title compound (1.51 g, 68%). LC-MS: tR=0.89 min; ES+: 669.09.

Provenance & Evidence