7-{3-[3-(3-Chloro-2,6-difluorophenoxy)propyl]isoxazol-5-yl}-6-[cyclopropyl-(2,3-dichlorobenzyl)carbamoyl]-3,9-diazabicyclo[3.3.1]non-6-ene-3,9-dicarboxylic acid di-tert-butyl ester → 7-{3-[3-(3-Chloro-2,6-difluorophenoxy)propyl]isoxazol-5-yl}-3,9-diazabicyclo[3.3.1]non-6-ene-6-carboxylic acid cyclopropyl-(2,3-dichlorobenzyl)amide

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	7-{3-[3-(3-Chloro-2,6-difluorophenoxy)propyl]isoxazol-5-yl}-6-[cyclopropyl-(2,3-dichlorobenzyl)carbamoyl]-3,9-diazabicyclo[3.3.1]non-6-ene-3,9-dicarboxylic acid di-tert-butyl ester	HCID 69088181	—
Edukt	Trichloro-tert-butylcarbamate	HCID 131729530	—
Katalysator	Zinc	HCID 23994	—
Lösungsmittel	Acetic acid tetrahydrofuran	HCID 23444217	—
Produkt	7-{3-[3-(3-Chloro-2,6-difluorophenoxy)propyl]isoxazol-5-yl}-3,9-diazabicyclo[3.3.1]non-6-ene-6-carboxylic acid cyclopropyl-(2,3-dichlorobenzyl)amide	HCID 68570839	—

Reaktionsschritte

This compound is prepared from compound F9, according to the above-described procedure B. After cleaving the Boc-group the trichloro-tert-butylcarbamate was cleaved using Zn-powder in THF/AcOH 3:1. LC-MS: tR=0.90 min; ES+: 637.24.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US08138340B2
Quelldatensatz	uspto-grants-2012_03
ORD ID	ord-37ddbd1b0a6745f9be5e27454b229496
Quellennotiz	uspto-grants-2012_03