HuagongsheHuagongshe Chemistry Print Report · For research reference only
7-{3-[3-(4-Chloro-3,5-dimethylphenoxy)propyl]isoxazol-5-yl}-6-[cyclopropyl-(2,3-dichlorobenzyl)carbamoyl]-3,9-diazabicyclo[3.3.1]non-6-ene-3,9-dicarboxylic acid di-tert-butyl ester → 7-{3-[3-(4-Chloro-3,5-dimethylphenoxy)propyl]isoxazol-5-yl}-3,9-diaza-bicyclo[3.3.1]non-6-ene-6-carboxylic acid cyclopropyl-(2,3-dichlorobenzyl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 7-{3-[3-(4-Chloro-3,5-dimethylphenoxy)propyl]isoxazol-5-yl}-6-[cyclopropyl-(2,3-dichlorobenzyl)carbamoyl]-3,9-diazabicyclo[3.3.1]non-6-ene-3,9-dicarboxylic acid di-tert-butyl ester | HCID 68571289 | — |
| Reactant | Trichloro-tert-butylcarbamate | HCID 131729530 | — |
| Catalyst | Zinc | HCID 23994 | — |
| Solvent | Acetic acid tetrahydrofuran | HCID 23444217 | — |
| Product | 7-{3-[3-(4-Chloro-3,5-dimethylphenoxy)propyl]isoxazol-5-yl}-3,9-diaza-bicyclo[3.3.1]non-6-ene-6-carboxylic acid cyclopropyl-(2,3-dichlorobenzyl)-amide | HCID 68571189 | — |
Reaction Steps
This compound is prepared from compound F15, according to the above-described procedure B. After cleaving the Boc-group the trichloro-tert-butylcarbamate was cleaved using Zn-powder in THF/AcOH 3:1. LC-MS: tR=0.93 min; ES+: 629.33.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08138340B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-fd209ccb37c343ce84d6f4fcc9d5aa1d |
| Source note | uspto-grants-2012_03 |