1-Hydroxybenzotriazole → HCID 178466807, compound

Participants

Reaction Steps

Et3N (200 μL), HOBT (110 mg) and WSC hydrochloride (138 mg) were added to a DMF (4 mL) solution of 3,5-diethoxy-4-(6-fluoropyridin-3-yl)benzoic acid (186 mg) and 6-(tetrazol-5-yl)spiro[chroman-2,4′-piperidin]-4-one hydrochloride (231 mg), and stirred overnight at room temperature. Water was added to the reaction liquid, the formed solid was taken out through filtration, and the solid was washed with water and ether. The solid was dried under reduced pressure to obtain the title compound. 1H-NMR (400 MHz, DMSO-d6) δ: 8.42 (1H, d, J=4.0 Hz), 8.24 (1H, dd, J=8.0, 4.0 Hz), 8.13 (1H, s), 7.89 (1H, dt, J=8.0, 4.0 Hz), 7.32 (1H, d, J=8.0 Hz), 7.18 (1H, dd, J=8.0, 4.0 Hz), 6.75 (2H, s), 4.32-4.18 (1H, m), 4.08 (4H, q, J=8.0 Hz), 3.64-3.20 (3H, m), 2.98 (2H, s), 2.10-1.75 (4H, m), 1.17 (6H, t, J=8.0 Hz). MS [M+H]+=573.

Provenance & Evidence