Sodium Hydroxide → HCID 24998400, compound

Participants

Reaction Steps

Aqueous 1 N sodium hydroxide solution (0.75 mL) was added to a solution of Methyl 5-{1′-[3-ethoxy-5-methoxy-4-(1-methyl-1H-pyrazol-4-yl)benzoyl]-4-oxospiro[chroman-2,4′-piperidin]-6-yl}nicotinate in MeOH (2 ml) and THF (2 ml) and stirred at room temperature for over night. The organic solvent was evaporated and diluted with water. Aqueous 1N HCl aq. (1 ml) was added thereto at room temperature, and the resulted solid was collected and recrystallized from MeOH to afford the intended compound as a colorless solid. 1H-NMR (DMSO-d6) δ: 9.08 (1.0H, d, J=2.2 Hz), 9.02 (1.0H, d, J=1.7 Hz), 8.41 (1.0H, dd, J=2.2, 1.7 Hz), 8.07-8.03 (3.0H, m), 7.88 (1.0H, d, J=0.5 Hz), 7.27-7.24 (1.0H, m), 6.72-6.70 (2.0H, m), 4.33-4.19 (1.0H, br m), 4.09 (2.0H, q, J=7.0 Hz), 3.85 (3.0H, s), 3.83 (3.0H, s), 3.67-3.11 (3.0H, br m), 2.94 (2.0H, s), 2.12-1.89 (2.0H, br m), 1.84-1.77 (2.0H, m), 1.37 (3.0H, t, J=7.0 Hz). MS [M+H]+=597.

Provenance & Evidence