Hydrochloric Acid → 1-Methyl-3-phenyl-1H-indazole-6-carboxylic acid

Participants

Reaction Conditions

Reaction Steps

In a 50-mL egg plant-type flask, aqueous 5 N sodium hydroxide solution (1.3 mL, 6.5 mmol) was added to a THF (5 mL)-methanol (5 mL) mixed solution of methyl 1-methyl-3-phenyl-1H-indazole-6-carboxylate (604 mg, 22 mmol), and stirred overnight at 60° C. With cooling with ice, aqueous 5 N hydrochloric acid solution (1.3 mL, 6.5 mmol) was added to the reaction solution, and concentrated to obtain a mixture of the title compound with salt, as a colorless solid.

Provenance & Evidence