Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Tetramethyltin | HCID 11661 | — |
| Reactant | HCID 57931016 | HCID 57931016 | — |
| Catalyst | HCID 178418476 | HCID 178418476 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 57930922 | HCID 57930922 | — |
Reaction Steps
The mixture of tetramethyltin (1.14 ml), and PdCl2(PPh3)2 (97 mg), tert-butyl 6-[6-chloro-5-(methoxycarbonyl)-3-pyridinyl]-4-oxospiro[chroman-2,4′-piperidine]-1′-carboxylate (1.35 g) in dioxane (13 ml) was stirred at 180° C. for 15 min under microwave irradiation. The reaction mixture was evaporated, and purified by silica gel chromatography (hexane/ethyl acetate) to give the intended compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08138197B2 |
|---|
| Source dataset | uspto-grants-2012_03 |
|---|
| ORD ID | ord-d1999162602f48ac9e31d8a1ccde7758 |
|---|
| Source note | uspto-grants-2012_03 |
|---|
