Sodium Hydroxide → 3-Methyl-1-phenyl-1H-indazole-5-carboxylic acid

HRID 1097008Notes

Reaction equation

HRID 1097008 reaction equation
[OH-].[Na+].[CH3:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([C:13]([O:15]C)=[O:14])[CH:11]=2)[N:6]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[N:5]=1>CO>[CH3:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([C:13]([OH:15])=[O:14])[CH:11]=2)[N:6]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[N:5]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 57930953Methyl 3-methyl-1-phenyl-1H-indazole-5-carboxylate

Product 1

HCID 579309543-Methyl-1-phenyl-1H-indazole-5-carboxylic acid

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
50 °C

Procedure

5N NaOH aqueous solution (6 ml) was added to the solution of methyl 3-methyl-1-phenyl-1H-indazole-5-carboxylate (2.66 g) in methanol 30 ml and stirred at 50° C. for over night. The cooled reaction mixture was quenched with 1N HCl aqueous solution (33 ml) and white precipitate was collected and dried in vacuo at 60° C. to give the title compound as a colorless solid

Workup

  1. customThe cooled reaction mixture
  2. customwas quenched with 1N HCl aqueous solution (33 ml) and white precipitate
  3. customwas collected
  4. customdried in vacuo at 60° C.

Sources & evidence

ORD record
ord-69ffca3d14904635b49dad712b076f73
Source dataset
uspto-grants-2012_03
Patent number
US08138197B2

Reaction notes

Loading…