反应详情

To a solution of 5-(4-nitro-phenyl)-1H-tetrazole (1.0 g, 5.2 mmol) in MeOH (30 mL) was added 10 wt % Pd/C (0.1 equiv by wt) under argon atmosphere. The mixture was evacuated, refilled with hydrogen (3 cycles) and stirred at room temperature for 1.5 h. The heterogeneous reaction mixture was filtered through a pad of Celite, washed with MeOH and concentrated in vacuo. The crude amino-compound was used in the next step without purification. MS (ES+): m/z 162 (M+H)+.

1. customThe mixture was evacuated
2. additionrefilled with hydrogen (3 cycles)
3. filtrationThe heterogeneous reaction mixture was filtered through a pad of Celite
4. washwashed with MeOH
5. concentrationconcentrated in vacuo
6. customThe crude amino-compound was used in the next step without purification