Ethyl 6-((4,7-bis((6-(ethoxycarbonyl)-4-(2,4,6-trimethoxyphenyl)-pyridin-2-yl)methyl)-1,4,7-triazonan-1-yl)methyl)-4-(2,4,6-trimethoxyphenyl)-pyridine-2-carboxylate → 6-((4,7-bis((6-carboxy-4-(2,4,6-trimethoxyphenyl)pyridin-2-yl)methyl)-1,4,7-triazonan-1-yl)methyl)-4-(2,4,6-trimethoxyphenyl)pyridine-2-carboxylic Acid Terbium(III)
Reaction equation
C([O:3][C:4]([C:6]1[N:11]=[C:10]([CH2:12][N:13]2[CH2:21][CH2:20][N:19]([CH2:22][C:23]3[CH:28]=[C:27]([C:29]4[C:34]([O:35][CH3:36])=[CH:33][C:32]([O:37][CH3:38])=[CH:31][C:30]=4[O:39][CH3:40])[CH:26]=[C:25]([C:41]([O:43]CC)=[O:42])[N:24]=3)[CH2:18][CH2:17][N:16]([CH2:46][C:47]3[N:52]=[C:51]([C:53]([O:55]CC)=[O:54])[CH:50]=[C:49]([C:58]4[C:63]([O:64][CH3:65])=[CH:62][C:61]([O:66][CH3:67])=[CH:60][C:59]=4[O:68][CH3:69])[CH:48]=3)[CH2:15][CH2:14]2)[CH:9]=[C:8]([C:70]2[C:75]([O:76][CH3:77])=[CH:74][C:73]([O:78][CH3:79])=[CH:72][C:71]=2[O:80][CH3:81])[CH:7]=1)=[O:5])C.[Cl-].[Tb+3:83].[Cl-].[Cl-]>>[Tb+3:83].[C:41]([C:25]1[N:24]=[C:23]([CH2:22][N:19]2[CH2:18][CH2:17][N:16]([CH2:46][C:47]3[CH:48]=[C:49]([C:58]4[C:63]([O:64][CH3:65])=[CH:62][C:61]([O:66][CH3:67])=[CH:60][C:59]=4[O:68][CH3:69])[CH:50]=[C:51]([C:53]([OH:55])=[O:54])[N:52]=3)[CH2:15][CH2:14][N:13]([CH2:12][C:10]3[N:11]=[C:6]([C:4]([OH:5])=[O:3])[CH:7]=[C:8]([C:70]4[C:71]([O:80][CH3:81])=[CH:72][C:73]([O:78][CH3:79])=[CH:74][C:75]=4[O:76][CH3:77])[CH:9]=3)[CH2:21][CH2:20]2)[CH:28]=[C:27]([C:29]2[C:30]([O:39][CH3:40])=[CH:31][C:32]([O:37][CH3:38])=[CH:33][C:34]=2[O:35][CH3:36])[CH:26]=1)([OH:43])=[O:42]Participants
3
Reactant 2
Product 1
Procedure
Deprotection of compound 21 followed by treatment with terbium chloride as described in Example 20 yielded the title compound.
Sources & evidence
- ORD record
- ord-a8c53afc42c44395834ba1fa0dab1773
- Source dataset
- uspto-grants-2012_03
- Patent number
- US08143057B2
Reaction notes
Loading…