Sodium Nitrite → HCID 59547219, compound

Participants

Reaction Steps

Nitration of methyl 5-methylselenophene-2-carboxylate provided methyl 5-methyl-4-nitroselenophene-2-carboxylate. The nitro functionality is reduced to amines using suitable reducing agents, for example, iron powder or any other nitro reducing agents in good yield. Diazotization of methyl-amino-5-methylselenophene-2-carboxylate with sodium nitrite followed by treatment with potassium carbonate/dimethylamine provides methyl 4-[(dimethylamino)diazenyl]-5-methylselenophene-2-carboxylate. Treatment of the ester with ammonia gave the required 4-[(dimethylamino)diazenyl]-5-methylselenophene-2-carboxamide (compound 1).

Provenance & Evidence