Potassium Carbonate → HCID 59362312, compound

Participants

Reaction Steps

A solution of 1-(4-(6-Piperidin-1-ylmethyl-pyridin-2-yl)benzyl)imidazolidine-2,4-dione (example 134) (120 mg, 0.33 mmol), potassium carbonate (137 mg, 0.99 mmol) and 3-bromo-1,1,1-trifluoropropane (117 mg, 0.66 mmol) in DMF (2.5 ml) was stirred during 17 h at 50° C. After cooling to room temperature the reaction mixture was quenched by the addition of water. The product was extracted into ethylacetate and the combined organic phases were washed with brine, dried over sodium sulfate and concentrated under reduced pressure. Column chromatography afforded the title compound (50 mg) as a white solid.

Provenance & Evidence