2-Fluoro-5-nitroaniline → 2-(3-Hydroxypyrrolidin-1-yl)-5-nitroaniline

HRID 1097251Notes

Reaction equation

HRID 1097251 reaction equation
F[C:2]1[CH:8]=[CH:7][C:6]([N+:9]([O-:11])=[O:10])=[CH:5][C:3]=1[NH2:4].[OH:12][CH:13]1[CH2:17][CH2:16][NH:15][CH2:14]1>>[OH:12][CH:13]1[CH2:17][CH2:16][N:15]([C:2]2[CH:8]=[CH:7][C:6]([N+:9]([O-:11])=[O:10])=[CH:5][C:3]=2[NH2:4])[CH2:14]1

Participants

3

Reactant 2

HCID 677852-Fluoro-5-nitroanilineHCID 982104-Hydroxypyrrolidine

Product 1

HCID 629186892-(3-Hydroxypyrrolidin-1-yl)-5-nitroanilineYield 46.6%

Procedure

According to a process similar to that described in Example II-1, starting from 3 g (19.22 mmol) of 2-fluoro-5-nitroaniline and 1.76 ml (21.14 mmol) of 3-hydroxypyrrolidine, 2 g of expected compound are obtained in the form of a yellow solid.

Sources & evidence

ORD record
ord-5d39718dc6a1477ab72e65ca1da3d633
Source dataset
uspto-grants-2012_03
Patent number
US08143248B2

Reaction notes

Loading…