N-(1-Ethyl-hexahydro-5-methyl-2,4,6-trioxo-5-pyrimidinyl)-2,3,4,5-tetrafluorobenzamide → N-(1-Cyclohexyl-hexahydro-5-methyl-2,4,6-trioxo-5-pyrimidinyl)-2,3,4,5-tetrafluorobenzamide

HRID 1097281Notes

Reaction equation

HRID 1097281 reaction equation
[CH2:1]([N:3]1[C:8](=[O:9])[C:7]([NH:11][C:12](=[O:23])[C:13]2[CH:18]=[C:17]([F:19])[C:16]([F:20])=[C:15]([F:21])[C:14]=2[F:22])([CH3:10])[C:6](=[O:24])[NH:5][C:4]1=[O:25])[CH3:2].NC1(C)C(=O)N([CH:34]2[CH2:39]CC[CH2:36][CH2:35]2)C(=O)NC1=O>>[CH:1]1([N:3]2[C:8](=[O:9])[C:7]([NH:11][C:12](=[O:23])[C:13]3[CH:18]=[C:17]([F:19])[C:16]([F:20])=[C:15]([F:21])[C:14]=3[F:22])([CH3:10])[C:6](=[O:24])[NH:5][C:4]2=[O:25])[CH2:36][CH2:35][CH2:34][CH2:39][CH2:2]1

Participants

3

Reactant 2

HCID 24765666N-(1-Ethyl-hexahydro-5-methyl-2,4,6-trioxo-5-pyrimidinyl)-2,3,4,5-tetrafluorobenzamideHCID 668107655-Amino-1-cyclohexyl-5-methylbarbituric acid

Product 1

HCID 24765665N-(1-Cyclohexyl-hexahydro-5-methyl-2,4,6-trioxo-5-pyrimidinyl)-2,3,4,5-tetrafluorobenzamide

Procedure

Compound 20h was prepared by the same method described for 20f using 5-amino-1-cyclohexyl-5-methylbarbituric acid (0.48 g, 2 mmol). The crude 1-cyclohexyl-5-methyl-5-(tetrafluorobenzamido)barbituric acid (20h) was obtained as yellow crystals and did not require further purification.

Workup

  1. customCompound 20h was prepared by the same method

Sources & evidence

ORD record
ord-3bdd40c5995a42ccb1ac96df7007dc73
Source dataset
uspto-grants-2012_03
Patent number
US08143252B2

Reaction notes

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