Hydrochloric Acid → HCID 66811254, compound

Participants

Reaction Steps

Boc-protected piperazine 9 (4.00 g, 10.30 mmol) was dissolved in methanol (45 mL). The solution was cooled in an ice bath. Ethereal hydrogen chloride (30 mL) was added slowly in three portions. A precipitate formed as the reaction stirred at room temperature for 14 hours. The white solid was collected by vacuum filtration and dried under vacuum to give piperazine dihydrochloride salt 10 (3.35 g, 90%): 1H NMR (500 MHz, DMSO-d6) δ 1.62-1.71 (m, 4H), 3.11-3.17 (m, 5H), 2.39-3.41 (m, 2H), 3.48-3.77 (m, 4H), 7.83-7.91 (m, 4H), 9.33 (br, 2H), 11.54 (br, 1H); ESI MS m/z 288 [C16H21N3O2+H]+.

Provenance & Evidence