Hydrochloric Acid → HCID 66811501, compound

Participants

Reaction Conditions

Reaction Steps

In a sealable vessel, the acid-amide 12 (0.22 g, 0.55 mmol) was dissolved in concentrated hydrochloric acid (5 mL). The reaction vessel was sealed and heated to 100° C. for 9 hours, and then cooled to 0° C. The precipitate was collected by vacuum filtration. The collected solids were dried under vacuum to give 13 (0.19 g, 95%) as an off-white solid: 1H NMR (300 MHz, CD3OD) δ 1.78-2.15 (m, 8H), 2.45-2.56 (m, 3H), 3.01 (t, J=7.30 Hz, 2H), 3.31-3.42 (m, 6H), 3.57-4.51 (m, 6H). Compound 13 was employed in the next reaction without further purification

Provenance & Evidence