化工社化工社 化学情報印刷レポート · 研究参考用
Trifluoroacetic acid methylene chloride → 3-benzyloxycarbonylamino-6-methyl-4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidine-6-carboxylic Acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Trifluoroacetic acid methylene chloride | HCID 21863450 | — |
| 反応物 | 3-benzyloxycarbonylamino-6-methyl-4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidine-6-carboxylic Acid tert-butyl Ester | HCID 69600879 | — |
| 触媒 | Water | HCID 962 | — |
| 生成物 | 3-benzyloxycarbonylamino-6-methyl-4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidine-6-carboxylic Acid | HCID 21979698 | 105.5% |
反応手順
A solution of intermediate 19a (55 mg, 0.138 mmol) in 4 mL 1:1 TFA/CH2Cl2 with 2 drops water was stirred at rt for 12 h. The mixture was concentrated in vacuo, then coevaporated with CCl4 to afford 50 mg of intermediate 19b (quantitative), which was used without further purification in the following step.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07094783B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-87b4f71a3c464d95bdbbcf9b03be006a |
| 出典メモ | uspto-grants-2006_08 |