Ethanolamine → HCID 25174615, compound

Participants

Reaction Conditions

Reaction Steps

4-[3-(3-Pyrazol-1-yl-phenyl)-imidazo[1,2-b]pyridazin-7-yl]-benzoic acid ethyl ester (Ex. 34) (1 eq, 0.073 mmol, 30 mg) and ethanol amine (10 eq, 0.73 mmol, 0.04 ml) are dissolved in EtOH (2 ml) and K2CO3 (1.5 eq, 0.11 mmol, 15.1 mg) is added. The reaction mixture is stirred for 5 h at 55° C. The solvent is then removed in vacuo and the reaction is purified by flash column chromatography eluting with 9:1 DCM/MeOH to yield N-(2-Hydroxy-ethyl)-4-[3-(3-pyrazol-1-yl-phenyl)-imidazo-[1,2-b]-pyridazin-7-yl]-benzamide as a yellow solid; [M+H]+=425

Provenance & Evidence