HCID 59443498, compound → HCID 135856876, compound

HRID 1097308Notes

Reaction equation

HRID 1097308 reaction equation
C1(C2C=C(C3N4N=CC(C5C=C(C=CC=5)C(O)=O)=CC4=NC=3)C=CN=2)C=CC=CC=1.C([O:33][C:34](=[O:59])[C:35]1[CH:40]=[CH:39][CH:38]=[C:37]([C:41]2[CH:46]=[N:45][N:44]3[C:47]([C:50]4[CH:55]=[CH:54][C:53]([OH:56])=[C:52]([O:57][CH3:58])[CH:51]=4)=[CH:48][N:49]=[C:43]3[CH:42]=2)[CH:36]=1)C>>[OH:56][C:53]1[CH:54]=[CH:55][C:50]([C:47]2[N:44]3[N:45]=[CH:46][C:41]([C:37]4[CH:36]=[C:35]([CH:40]=[CH:39][CH:38]=4)[C:34]([OH:59])=[O:33])=[CH:42][C:43]3=[N:49][CH:48]=2)=[CH:51][C:52]=1[O:57][CH3:58]

Participants

3

Reactant 2

HCID 59443498HCID 59443498, compoundHCID 135856867HCID 135856867, compound

Product 1

HCID 135856876HCID 135856876, compound

Procedure

This example is prepared by an analogous method to 3-[3-(2-Phenyl-pyridin-4-yl)imidazo[1,2-b]pyridazin-7-yl]benzoic acid (Ex. 52) by replacing 3-[3-(2-Phenyl-pyridin-4-yl)-imidazo[1,2-b]pyridazin-7-yl]-benzoic acid ethyl ester (Ex 42) with 3-[3-(4-Hydroxy-3-methoxy-phenyl)-imidazo[1,2-b]pyridazin-7-yl]-benzoic acid ethyl ester (Ex. 40).

Sources & evidence

ORD record
ord-be8a8425669a44579b60300d446a24b9
Source dataset
uspto-grants-2012_03
Patent number
US08143253B2

Reaction notes

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