N-bromobutanimide → 3-(3-Bromo-imidazo-[1,2-b]-pyridazin-7-yl)-N-methyl-benzamide

Participants

Reaction Conditions

Reaction Steps

3-Imidazo-[1,2-b]-pyridazin-7-yl-N-methyl-benzamide (1 eq, 0.595 mmol, 150 mg) is dissolved in DMF (5 ml) at 0° C. and NBS (1.1 eq, 0.654 mmol, 116 mg) is added. The reaction mixture is stirred for 1 h at 0° C. and then is diluted with EtOAc. The reaction mixture is washed with NaHCO3 and brine, dried over MgSO4, filtered and evaporated to yield 3-(3-Bromo-imidazo-[1,2-b]-pyridazin-7-yl)-N-methyl-benzamide as a pale yellow solid which did not require further purification; [M+H]+=333

Provenance & Evidence