反应详情

A mixture of 3-chloro-2-fluorobenzylbromide (5.0 g), thiourea (3.4 g) in a solvent of ethanol (200 ml) was heated under reflux for 16 hours. The mixture was evaporated to dryness and to the residue was added a solution of sodium hydroxide (30 g) in water (300 ml) and the mixture heated under reflux for 1 hour. Allowed to cool to room temperature and acidified with concentrated hydrochloric acid, the product was extracted into ether to give the subtitle compound as an oil (2.51 g).

1. temperaturewas heated
2. temperatureunder reflux for 16 hours
3. customThe mixture was evaporated to dryness and to the residue
4. additionwas added a solution of sodium hydroxide (30 g) in water (300 ml)
5. temperaturethe mixture heated
6. temperatureunder reflux for 1 hour
7. extractionthe product was extracted into ether