Hydrochloric Acid → 2-[[5-[[(2-fluorophenyl)methyl]thio]-2-methoxythiazolo[4,5-d]pyrimidin-7-yl]amino]-(2R)-1-propanol

Participants

Role	Name	HCID	Charge
Reactant	Hydrochloric Acid	HCID 313	—
Reactant	Methanol	HCID 887	—
Reactant	Potassium Hydroxide	HCID 14797	—
Reactant	2-[[2-bromo-5-[[(2-fluorophenyl)methyl]thio]thiazolo[4,5-d]pyrimidin-7-yl]amino]-(2R)-1-propanol	HCID 23519830	—
Product	2-[[5-[[(2-fluorophenyl)methyl]thio]-2-methoxythiazolo[4,5-d]pyrimidin-7-yl]amino]-(2R)-1-propanol	HCID 23519841	—

Reaction Steps

Potassium hydroxide (27 mg) was added to a solution of the product of example 32 step d) (0.1 g) in MeOH (10 ml). The mixture was stirred for 24 h before neutralising to pH 7 with 2M HCl solution. The volatiles were removed in vacuo and the product used directly in the following step.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08143261B2
Source dataset	uspto-grants-2012_03
ORD ID	ord-5190058fe4494eeb962ad03fb95a17ea
Source note	uspto-grants-2012_03