HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 5-[[(2-fluorophenyl)methyl]thio]-7-[[(1R)-2-hydroxy-1-methylethyl]amino]thiazolo[4,5-d]pyrimidin-2(3H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | 2-[[5-[[(2-fluorophenyl)methyl]thio]-2-methoxythiazolo[4,5-d]pyrimidin-7-yl]amino]-(2R)-1-propanol | HCID 23519841 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 5-[[(2-fluorophenyl)methyl]thio]-7-[[(1R)-2-hydroxy-1-methylethyl]amino]thiazolo[4,5-d]pyrimidin-2(3H)-one | HCID 23519852 | — |
Reaction Steps
The product of example 32 step e) was dissolved in 1,4-dioxane (50 ml), H2O (1 ml) and concentrated HCl solution (0.5 ml) and stirred for 20 h at 40° C. The volatiles were removed under reduced-pressure and the crude product purified by preparative HPLC to afford the subtitle compound as a white solid (21 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08143261B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-b89cc663241a4bbdbdf52d6708847032 |
| Source note | uspto-grants-2012_03 |