5-Chloro-4-(chloromethyl)-1,2,3-thiadiazole → (2R)-2-[[2-amino-5-[(5-chloro-1,2,3-thiadiazol-4-yl)thio]thiazolo[4,5-d]pyrimidin-7-yl]amino]-1-propanol

HRID 1097372Notes

Reaction equation

HRID 1097372 reaction equation
[NH2:1][C:2]1[S:3][C:4]2[C:9]([NH:10][C@H:11]([CH3:14])[CH2:12][OH:13])=[N:8][C:7]([SH:15])=[N:6][C:5]=2[N:16]=1.[Cl:17][C:18]1[S:22][N:21]=[N:20][C:19]=1CCl>>[NH2:1][C:2]1[S:3][C:4]2[C:9]([NH:10][C@H:11]([CH3:14])[CH2:12][OH:13])=[N:8][C:7]([S:15][C:19]3[N:20]=[N:21][S:22][C:18]=3[Cl:17])=[N:6][C:5]=2[N:16]=1

Participants

3

Reactant 2

HCID 27974905-Chloro-4-(chloromethyl)-1,2,3-thiadiazoleHCID 178461804HCID 178461804, compound

Product 1

HCID 86635808(2R)-2-[[2-amino-5-[(5-chloro-1,2,3-thiadiazol-4-yl)thio]thiazolo[4,5-d]pyrimidin-7-yl]amino]-1-propanol

Procedure

Prepared by the method of example 32 step c), using the product of example 32 step b) and 5-chloro-4-(chloromethyl)-1,2,3-thiadiazole.

Workup

  1. customPrepared by the method of example 32 step c),

Sources & evidence

ORD record
ord-17fb4c49666044df809deafaffd0bf4d
Source dataset
uspto-grants-2012_03
Patent number
US08143261B2

Reaction notes

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