反应详情

In dry MC, dissolved was 1-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]ethanol (24 g, 93 mmol), and PCC (pyridinium chlorochromate) (30 g, 139 mmol) was added thereto. The resultant mixture was heated under reflux. The reaction mixture was filtered through Celite, and the filtrate was extracted with EA, washed twice with brine, dried over MgSO4 and filtered. After removing the solvent by evaporation under reduced pressure, the mixture was purified via column chromatography (n-hexane/MC=7/1) to obtain 1-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]ethanone (19 g, 91%).

1. dissolutionIn dry MC, dissolved
2. additionwas added
3. temperatureunder reflux
4. filtrationThe reaction mixture was filtered through Celite
5. extractionthe filtrate was extracted with EA
6. washwashed twice with brine
7. dry with materialdried over MgSO4
8. filtrationfiltered
9. customAfter removing the solvent
10. customby evaporation under reduced pressure
11. customthe mixture was purified via column chromatography (n-hexane/MC=7/1)