Nicotinic acid, hydrazide → HCID 178508303, compound

Participants

Reaction Conditions

Reaction Steps

Nicotinic acid hydrazide (10.0 g, 72.92 mmol) was dissolved in aq. NaOH (4.38 g, 109.38 mmol), and 2-methyl-2-thiopseudourea sulfate (12.16 g, 87.50 mmol) was slowly added thereto. The resultant mixture was stirred at room temperature. The reaction mixture was filtered, washed with water and Et2O, and dried. The solid obtained was heated to 230° C. to obtain the desired compound, 5-(pyridin-3-yl)-2H-[1,2,4]triazol-3-amine (9.2 g, 78%).

Provenance & Evidence