Sulfuric Acid → HCID 178506408, compound

Participants

Reaction Steps

In methylene chloride, dissolved was 7-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2-pyridin-3-yl-[1,2,4]triazolo[1,5-a]pyrimidine (Compound 101) (0.03 g, 0.73 mmol), and 95% sulfuric acid (0.008 g, 0.08 mmol) was added thereto. The mixture was stirred at room temperature for 1 hour. When the reaction was completed, the solid produced was filtered, washed with Et2O, and dried to obtain the desired compound, 3-[7-{3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl}-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl]-pyridinium bisulfate (Compound 111) (0.024 g, 64.7%).

Provenance & Evidence