反应详情

To a solution of sodium borohydride (3.0 g, 79.4 mmol) in is ethanol (30 mL) was added dropwise methanol (6 mL). To this suspension was added N-(5-{[2-(acetylamino)-7-cyano-1,3-benzothiazol-6-yl]oxy}-2-fluorophenyl)-2,2,2-trifluoroacetamide (700 mg, 1.60 mmol). The reaction mixture was stirred at room temperature for 20 min, and concentrated under reduced pressure. The obtained residue was diluted with ethyl acetate (150 mL), washed successively with saturated aqueous sodium hydrogen carbonate solution (100 mL) and saturated brine (100 mL), and dried over anhydrous sodium sulfate. Insoluble material was filtered off, and the filtrate was concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography (ethyl acetate/n-hexane=50/50→100/0). The obtained solution was concentrated under reduced pressure to give the title compound (260 mg, 48%) as a white powder.

1. concentrationconcentrated under reduced pressure
2. additionThe obtained residue was diluted with ethyl acetate (150 mL)
3. washwashed successively with saturated aqueous sodium hydrogen carbonate solution (100 mL) and saturated brine (100 mL)
4. dry with materialdried over anhydrous sodium sulfate
5. filtrationInsoluble material was filtered off
6. concentrationthe filtrate was concentrated under reduced pressure
7. customThe obtained residue was purified by silica gel column chromatography (ethyl acetate/n-hexane=50/50→100/0)
8. concentrationThe obtained solution was concentrated under reduced pressure