Trifluoroacetic acid → HCID 66814793, compound

Participants

Reaction Conditions

Reaction Steps

Trifluoroacetic acid (28.15 mL, 365.5 mmol) was added to tert-butyl 3-{2-amino-4-[bis(4-methoxybenzyl)amino]-1H-imidazo[4,5-c]quinolin-1-yl}propylcarbamate hydrobromide (8.3 g), and the reaction was heated at 50° C. for four hours, allowed to cool to ambient temperature, and stirred at ambient temperature for three days. The volatiles were removed under reduced pressure. The residue was purified by automated flash chromagraphy (silica cartridge, eluting with aqueous ammonium hydroxide:methanol:dichloromethane in a gradient from 0.3:4.8:95 to 2.5:47.5:50) to provide 630 mg of 1-(3-aminopropyl)-1H-imidazo[4,5-c]quinoline-2,4-diamine.

Provenance & Evidence