Tert-butyl 2-[(2-chloro-3-nitroquinolin-4-yl)amino]ethylcarbamate → Tert-butyl 2-[(3-amino-2-chloroquinolin-4-yl)amino]ethylcarbamate

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Reaction Steps

Platinum on carbon (1.5 g of 5%) was added to a solution of tert-butyl 2-[(2-chloro-3-nitroquinolin-4-yl)amino]ethylcarbamate (13.99 g, 38.19 mmol) in acetonitrile (100 mL) in a Parr vessel. The mixture was placed under hydrogen pressure (30 psi, 2.1×105 Pa) for three hours and then filtered through a layer of CELITE filter agent. The filtrate was concentrated under reduced pressure and further dried overnight on a vacuum pump to provide 13.46 g of tert-butyl 2-[(3-amino-2-chloroquinolin-4-yl)amino]ethylcarbamate as a light brown solid.

Provenance & Evidence