HRID10976

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：C=CCC1(C(=O)O)CCc2ncc(NC(=O)OCc3ccccc3)c(=O)n21

HCID21979697

未命名化合物

HCID145832046

未命名化合物

PRODUCTS

生成物

结构：C=CCC1(C(=O)NCc2ccc(C(=N)NC(=O)OC(C)(C)C)cc2)CCc2ncc(NC(=O)OCc3ccccc3)c(=O)n21

HCID145857203

未命名化合物

收率 86%

PROCEDURE

实验过程

According to the procedure for the preparation of intermediate 19c, intermediate 20b (50 mg, 0.135 mmol) was coupled with [(4-aminomethyl-phenyl)-imino-methyl]-carbamic acid tert-butyl ester to afford 70 mg (86%) of intermediate 20c.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1f57f987a2284ab48972c433a6c34bef
来源数据集: uspto-grants-2006_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07094783B2
来源说明: uspto-grants-2006_08

反应 SMILES

[CH2:1]([C:4]1([C:25](O)=[O:26])[N:8]2[C:9](=[O:24])[C:10]([NH:13][C:14]([O:16][CH2:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[O:15])=[CH:11][N:12]=[C:7]2[CH2:6][CH2:5]1)[CH:2]=[CH2:3].[C:28]([O:32][C:33](=[O:45])[NH:34][C:35]([C:37]1[CH:42]=[CH:41][C:40]([CH2:43][NH2:44])=[CH:39][CH:38]=1)=[NH:36])([CH3:31])([CH3:30])[CH3:29]>>[CH2:17]([O:16][C:14](=[O:15])[NH:13][C:10]1[C:9](=[O:24])[N:8]2[C:4]([CH2:1][CH:2]=[CH2:3])([C:25](=[O:26])[NH:44][CH2:43][C:40]3[CH:39]=[CH:38][C:37]([C:35]([NH:34][C:33]([O:32][C:28]([CH3:31])([CH3:29])[CH3:30])=[O:45])=[NH:36])=[CH:42][CH:41]=3)[CH2:5][CH2:6][C:7]2=[N:12][CH:11]=1)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1