HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1097631Generated: October 27, 2026
Thionyl Chloride → 2-Methoxy-6-methylsulfanyl-4-trifluoromethyl-benzoyl chloride
https://huagongshe.com/reaction/1097631
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 2-Methoxy-6-methylsulfanyl-4-trifluoromethyl-benzoic acid | HCID 59197921 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 2-Methoxy-6-methylsulfanyl-4-trifluoromethyl-benzoyl chloride | HCID 59438501 | — |
Reaction Steps
A mixture of 51 mg (0.191 mmol) 2-methoxy-6-methylsulfanyl-4-trifluoromethyl-benzoic acid (CAS 1208984-79-5) and 140 ul (1.91 mmol) thionylchloride in toluene (0.5 ml) was heated in a 80° C. oil bath for 4 hours. The solvent was removed in vacuo to provide the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08143273B2 |
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| Source dataset | uspto-grants-2012_03 |
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| ORD ID | ord-51948dc15c544665aacad41140855ce3 |
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| Source note | uspto-grants-2012_03 |
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