関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | 1-Iodopropane | HCID 33643 | — |
| 反応物 | 7-Allyl-8-chloro-1H-purine-2,6(3H,7H)-dione | HCID 59299532 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 8-chloro-7-(2-propen-1-yl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione | HCID 59299567 | 46.2% |
反応手順
A mixture of 8-chloro-7-(2-propen-1-yl)-3,7-dihydro-1H-purine-2,6-dione (1.5 g, 6.6 mmol), 1-iodopropane (1.2 g, 6.9 mmol) and sodium carbonate (0.9 g, 8.5 mmol) in DMF (40 ml) was heated at 50° C. for 18 h. The reaction mixture was concentrated in vacuo and the residue treated with water (60 ml) and extracted with EtOAc (3×80 ml). The combined organic extracts were dried (MgSO4) filtered and evaporated. The residue was triturated with ether/cyclohexane, the solid was filtered off and dried to afford the title compound (0.82 g, 46%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08143264B2 |
|---|
| 出典データセット | uspto-grants-2012_03 |
|---|
| ORD ID | ord-e83b300d5b9f4568ba6a382636f15bc3 |
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| 出典メモ | uspto-grants-2012_03 |
|---|
