Sodium ethoxide → HCID 59395785, compound

Participants

Reaction Conditions

Reaction Steps

To ethyl 4-(3-butyl-8-chloro-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-1-yl)butanoate (185 mg, 0.52 mmol) and (1Z)-2-(3,5-dichlorophenyl)-N-hydroxyethanimidamide (126 mg, 0.58 mmol; Entry 23, Table 7) in dry EtOH (2 ml) was added 21% wt. ethanolic sodium ethoxide solution (0.29 ml, 0.78 mmol) and the mixture was heated by microwaves at 140° C. for 10 min. The reaction was worked up by partition between EtOAc and 2M HCl and evaporating the organic phase. Purification by MDAP afforded the title compound as a solid (135 mg).

Provenance & Evidence