Phenylsilane → HCID 59395498, compound

Participants

Reaction Steps

4-[3-Butyl-8-chloro-2,6-dioxo-7-(2-propen-1-yl)-2,3,6,7-tetrahydro-1H-purin-1-yl]butanenitrile (2.1 g, 6 mmol) was stirred in a mixture of nitrogen degassed DCM (20 ml) and AcOH (2 ml). Tetrakis(triphenylphosphine)palladium (675 mg, 0.6 mmol) and phenyl silane (7.4 ml, 60 mmol) were added and the mixture stirred at rt for 2 d. This was then evaporated and the residue triturated with a mixture of diethylether:cyclohexane (1:1) to afford the title compound (1.47 g, 60%) as a white solid.

Provenance & Evidence